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KMID : 0362820110300010009
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Journal of the Korean Academy of Implant Dentistry
2011 Volume.30 No. 1 p.9 ~ p.15
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Bone induction of human particulated demineralized dentin matrix in nude mice
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Kim Hyoun-Chull
Masaru Murata
Toshiyuki Akazawa
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Abstract
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Purpose: The aim of this study evaluated the osteoinductive properties of human demineralized dentin matrix (DDM) in the subcutaneous tissue in nude mice.
Materials & Method: A human demineralized dentin matrix was prepared from extracted vital 3rd molar and implanted into the subcutaneous tissue in nude mice. The demineralized dentin matrix was particulated and its size varied from 400 to 800㎛. The hard tissue inducted by 70 mg of the demineralized dentin matrix was estimated at 4weeks after implantation histomorphometrically.
Results: The demineralized dentin matrix induced bone and cartilage independently. Appositional forming of new bone was formed on the surface of demineralized dentin matrix and regular arrangement of osteoblasts were observed. Cartilage was observed between demineralized dentin matrix particles as a scaffold. Histological examination showed that the demineralized dentin matrix induced bone and cartilage, 0.9% and 0.4% in morphometric analysis, respectively. The demineralized dentin matrix occupied 74.7% in the volume of the total tissues.
Conclusion: This results showed that the human demineralized dentin matrix particles are osteoinductive insoluble matrices.
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KEYWORD
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Collagen, Dentin, Human, Purpose : The aim of this study evaluated the osteoinductive properties of human demineralized dentin matrix (DDM) in the Osteoinduction
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